Tomes/Disciplines
- Main article: Tome
- A Lure of Flames tome is on the number 2 floor of the Society of Leopold in a room in the third parallel hallway
- Obfuscate in the Setite Temple, also level 2, behind a triangle switch on the right
- A Potence is on the ground floor of the Tower of London in a dead end
Christof and Lily attain Domination after the first encounter with Lucretia in the Setite Temple; Christof receives Serpentis after the second, and this is unaffected by any choices. Pink receives Fortitude at the Apex of the Tower of London.
Humanity
There is 20 Humanity to be gained in London, and 40 lost; 10 of each is mutually exclusive. After meeting Lucretia, there are no more Humanity gains.
If the player wants the "Good" Ending and has less than 30 Humanity when they start London or less than 50 when they leave, they need a restart or earlier save. The previous gain was refusing to kill Luther Black, and the previous loss was avoided by insisting on going to Vysehrad Castle.
- Click on the blood vats to destroy them and halt Father Leo Alatius' assault. Killing him loses 10 Humanity.
- Setite Brothel: When Lily first sets eyes on Christof, "Perhaps you will be a valuable ally" despite its mercenary air, gains 10 points.
- "I trust no one in this foul place!" Loses 10.
- Pink wants to kill Lucretia when they first encounter her. "Nay, tell us of thy shipping routes and free Lily of the bonds of blood. Then we shall part in peace." Gains 10.
- Consume Lucretia's power from her heart and lose 20 humanity. It's also bugged
West London
Exit to East London
Society of Leopold
- Main article: Society of Leopold
Only one of the headquarters of the Society of Leopold, which is in turn only part of the Inquisition. Run with a tight and iron fist by the corrupt as well as zealous Father Leo Alatius. The Modern Times begins in the deepest part of the Society headquarters as Christof must escape
Curio Shop
When Pink accompanies Christof to his apothecary shop, Sumner Montague gives his visitors a somewhat chilly welcome. His name is an inversion of Montague Summers, a real life writer on the occult who banked credibility from a scholarly perspective of skepticism but made large cash withdrawals from the titillation his works evoked.
Club Tenebrae
Pink and a human bartender voiced by Wilhem Streicher's voice actor
East London
In the storyline, the weapon seller, the original model for Dominic's Malkavian army in Leaves of Three, pops out of a white van near the Bridge Haven. It is possible for him to sell many things, so if money is tight you may need to be patient. It is also possible he does not sell everything, and a fair bit of anecdotal evidence points to this being true. Even Patience cannot defeat Futility.
Underground
Exit to West London
Bridge Haven
Rest bed, Inventory chest. Weapon seller outside in white van.
Setite Brothel
Exit to East London and the Setite Temple
Setite Temple
- Main article: Setite Temple
Tower of London
- Main article: Tower of London
The Tower of London, for much of its history, was essentially a prison for political prisoners, and numerous inconvenient people were tortured and/or met their end here.
- Ghoul Spider
- Ghoul Spider Baby
- Wraith
- Vipers to guard Lucretia's Heart
- Werewolf outside after gaining the Heart. Skip by using Walk the Abyss, or evade and Revive as necessary.
The Monocle of Clarity, found at the end of the To Curse the Darkness multiplayer map. The London Tower theme is unique to this location. The Potence Tome is found on the first floor, at a dead end. Fortitude skill is given to Pink at the top of the tower.